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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
9.09
Human Site:
S273
Identified Species:
16.67
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
S273
A
P
R
E
H
L
G
S
Q
L
I
A
G
T
K
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
S273
A
P
R
E
H
L
G
S
Q
L
I
A
G
T
K
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
S273
A
P
R
E
H
L
G
S
Q
L
I
A
G
T
K
Dog
Lupus familis
XP_854529
779
87136
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
G270
A
P
P
R
E
R
F
G
S
Q
L
S
A
R
T
Rat
Rattus norvegicus
Q62865
1141
124282
G270
A
P
P
R
E
R
F
G
S
Q
S
S
A
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
L38
V
M
G
E
A
H
G
L
I
T
D
L
L
A
D
Frog
Xenopus laevis
NP_001088828
985
108702
G198
T
P
N
S
Y
Y
G
G
S
K
M
G
R
R
P
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
R207
P
E
Q
G
A
S
H
R
E
G
S
R
G
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
A208
E
L
D
Q
Q
L
S
A
A
D
I
A
A
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
G613
S
G
G
G
L
I
S
G
L
T
R
S
S
M
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
0
N.A.
13.3
13.3
N.A.
0
13.3
13.3
6.6
N.A.
20
N.A.
0
0
P-Site Similarity:
100
100
100
0
N.A.
26.6
20
N.A.
0
13.3
26.6
20
N.A.
33.3
N.A.
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
0
0
0
16
0
0
8
8
0
0
31
24
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
8
8
0
0
8
8
% D
% Glu:
8
8
0
31
16
0
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
16
16
0
0
39
31
0
8
0
8
31
0
0
% G
% His:
0
0
0
0
24
8
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
8
0
31
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
24
% K
% Leu:
0
8
0
0
8
31
0
8
8
24
8
8
8
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
47
16
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
8
8
8
0
0
0
24
16
0
0
0
0
0
% Q
% Arg:
0
0
24
16
0
16
0
8
0
0
8
8
8
24
0
% R
% Ser:
8
0
0
8
0
8
16
24
24
0
16
24
8
0
8
% S
% Thr:
8
0
0
0
0
0
0
0
0
16
0
0
0
24
24
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _